The total synthesis of the natural product endothelin converting enzyme (ECE) inhibitor, WS75624 B

DOI: 10.1016/S0040-4039(97)00076-2

Source and publish data:

Tetrahedron Letters p. 1297 - 1300 (1997)

Update date:2022-07-31

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Authors:

Patt, William C.

Massa, Mark A.

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Article abstract of DOI:10.1016/S0040-4039(97)00076-2

The first total synthesis of WS75624 B, 1, an endothelin converting enzyme inhibitor produced in a fermentation broth of Saccharothrix sp. No. 75624 is reported herein. WS75624 B is synthesized in 14 steps from commercially available kojic acid, 2. The synthetic methodology allows for facile substitution at multiple sites on the molecule.

Full text of DOI:10.1016/S0040-4039(97)00076-2

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