Soluble polymer synthesis: An improved traceless linker methodology for aliphatic C-H bond formation

Article abstract of DOI:10.1016/S0040-4039(96)02503-8

A traceless linker was developed on a soluble polymer support. The methodology allows for the facile attachment of molecules possessing an alkyl halide appendage. The coupled molecule can be further functionalized before subsequent cleavage via a two-step oxidation-reduction sequence. This sequence allows for the synthesis of molecules containing no trace of the linker and the formation of a new C-H bond.