Tetrahedron p. 2871 - 2890 (1997)
Update date:2022-08-04
Topics:
Ple, Nelly
Turck, Alain
Chapoulaud, Valerie
Queguiner, Guy
The first lithiation on the benzene moiety of 4-substituted quinazolines has been highlighted. According to the nature and position of various directing groups, an exceptional regioselective metallation occured at position C8, peri to the N-1 ring nitrogen. This method allows an easy access to a large range of new substituted quinazolines.
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(1997)
