Synthesis of N-acetylglucosaminyl- and N-acetylgalactosaminylceramides as cerebroside analogs and their anti-human immunodeficiency virus type 1 activities

DOI: 10.1248/cpb.45.402

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 402 - 405 (1997)

Update date:2022-08-05

Topics:

Authors:

Ikeda, Kiyoshi

Asahara, Tsuyoshi

Achiwa, Kazuo

Hoshino, Hiroo

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Article abstract of DOI:10.1248/cpb.45.402

Monoglycosylceramide derivatives containing mimicks of ceramide were synthesized as cerebroside analogs from D-glucosamine or D-galactosamine derivatives and N-benzyloxycarbonyl-L-serine myristylamide by using trimethylsilyl trifluoromethanesulfonate (TMSOTf) as a promoter. The synthesized sulfated glycolipids show moderate anti-HIV-1 activities.

Full text of DOI:10.1248/cpb.45.402

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Product name:N-benzyloxycarbonyl-O-(3,4,6-tri-O-acetyl 2-chloroacetylamino-2-deoxy-β-D-glucopyranosyl)-L-serine myristylamide

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