Tetrahedron Letters p. 1539 - 1540 (1997)
Update date:2022-09-26
Topics:
Oppolzer, Wolfgang
Rosset, Stephane
De Brabander, Jef
A very short, 4 step synthesis of 2-(4-isobutylphenyl)propionic acid (ibuprofen) was achieved in 57% overall. yield, using a highly diastereoselective alkylation of the chiral enolate derived from N-(4-isobutylphenyl)acetyl bornanesultam as a key step.
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Doi:10.1016/S0040-4039(97)00612-6
(1997)Doi:10.1021/ja970238w
(1997)Doi:10.1002/jhet.5570340210
(1997)Doi:10.1016/S0022-328X(96)06956-2
(1997)Doi:10.1021/jm00309a032
(1968)Doi:10.1016/S0022-328X(96)06877-5
(1997)
