Synthesis of 2,5- and 2,4-cyclohexadiene-1,3-dicarboxylates via reductive alkylation of isophthalates

Article abstract of DOI:10.1080/00397919708004199

Substituted 2,5-(structure 1) and 2,4-(structure 2) cyclohexadiene-1,3-dicarboxylates were prepared via Birch reductive alkylation of substituted isophthalates with alkylating agents such as alkyl and allyl halides, alkyl dihalides, α-halocarboxylates and expoxides. A brief discussion about their reactivity and stability is presented.

Full text of DOI:10.1080/00397919708004199

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Synthesis of 2,5- and
2,4-Cyclohexadiene-1,3-
dicarboxylates via Reductive
Alkylation of Isophthalates
Pierfausto Seneci a b , Marco Caspani a , Federica
Monti a , Lucia Carrano a , Sergio Lociuro a
Romeo Ciabatti a
&
a Lepetit Research Center , Via R. Lepetit 34,
21040, Gerenzano, VA, Italy
b Smith Kline Beecham, Unité de Recherche ,
4, Rue de Chesnay-Beuregard, 35760 Saint-
Grégoire Cedex, France Phone: 33-99280440
Fax: 33-99280440
Published online: 22 Aug 2006.
To cite this article: Pierfausto Seneci , Marco Caspani , Federica Monti , Lucia
Carrano , Sergio Lociuro & Romeo Ciabatti (1997) Synthesis of 2,5- and 2,4-
Cyclohexadiene-1,3-dicarboxylates via Reductive Alkylation of Isophthalates,
Synthetic Communications: An International Journal for Rapid Communication of
Synthetic Organic Chemistry, 27:5, 795-809, DOI: 10.1080/00397919708004199
To link to this article: http://dx.doi.org/10.1080/00397919708004199
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