Design, synthesis and biological evaluation of 1,3-diaminopropanes: A new class of polyamine analogs as leishmanicidal agents

Article abstract of DOI:10.1016/S0960-894X(97)00087-5

Analogs of 1,3-diaminopropane as inhibitors for the growth of Leishmania donovani have been synthesized and evaluated for their antileishmanial activity. Of the many active compounds, 1-(3-N,N-bis methoxycarbonyl guanidino)propyl-4- methylpiperidine piperazine (4e,f) exhibited significant in vivo inhibitory efficacy against L. donovani by oral and intraperitoneal route of administration.