Bioorganic and Medicinal Chemistry Letters p. 675 - 680 (1997)
Update date:2022-07-29
Topics:
Kumar, Versha Vinay
Singh, Sudhir K.
Sharma
Bhaduri
Gupta, Suman
Zaidi, Alima
Tiwari, Suman
Katiyar
Analogs of 1,3-diaminopropane as inhibitors for the growth of Leishmania donovani have been synthesized and evaluated for their antileishmanial activity. Of the many active compounds, 1-(3-N,N-bis methoxycarbonyl guanidino)propyl-4- methylpiperidine piperazine (4e,f) exhibited significant in vivo inhibitory efficacy against L. donovani by oral and intraperitoneal route of administration.
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(1997)
