Versatile raloxifene triflates

DOI: 10.1016/S0960-894X(97)00130-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 887 - 892 (1997)

Update date:2022-08-02

Topics:

Authors:

Martin, Michael J.

Grese, Timothy A.

Glasebrook, Andrew L.

Matsumoto, Ken

Pennington, Lewis D.

Phillips, D. Lynn

Short, Lorri L.

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Article abstract of DOI:10.1016/S0960-894X(97)00130-3

Methodology has been employed that permits the differentiation of the phenols of raloxifene. Transition metal mediated transformations of raloxifene triflates have subsequently provided a number of analogs that were evaluated further in two in vitro models predictive of estrogen receptor mediated biological activity.

Full text of DOI:10.1016/S0960-894X(97)00130-3

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