Bioorganic and Medicinal Chemistry Letters p. 887 - 892 (1997)
Update date:2022-08-02
Topics:
Martin, Michael J.
Grese, Timothy A.
Glasebrook, Andrew L.
Matsumoto, Ken
Pennington, Lewis D.
Phillips, D. Lynn
Short, Lorri L.
Methodology has been employed that permits the differentiation of the phenols of raloxifene. Transition metal mediated transformations of raloxifene triflates have subsequently provided a number of analogs that were evaluated further in two in vitro models predictive of estrogen receptor mediated biological activity.
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