Synthetic Communications p. 1631 - 1641 (1997)
Update date:2022-08-02
Topics:
Compagnone, Reinaldo S.
Suarez, Alirica I.
Zambrano, Jorge L.
Pina, Ivette C.
Dominguez, Jose N.
A short and versatile synthesis of a series of 3-substituted 2-aminoquinolines was accomplished in good yields starting from 2-nitrobenzaldehyde. Organic phosphonates were used as key synthetic intermediates and in some cases amino acids as readily available starting materials. The final two key steps of the sequence involving a reduction and ring closure that led to the 2-aminoquinoline skeleton were carried out in a 'one pot' procedure using SnCL22H2O.
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