Cladinose analogues of sixteen-membered macrolide antibiotics III. Efficient synthesis of 4-0-alky-L-cladinose analogues: Improved antibacterial activities compatible with pharmacokinetics

Article abstract of DOI:10.7164/antibiotics.50.32

The synthesis and biological evaluation of sixteen-membered macrolides possessing a 4-0-alkyl-α-L-cladinosyl moiety as a neutral sugar are described. These potent novel derivatives have been efficiently synthesized avoiding glycosylations. Two hydroxyl gr