Synthesis of ribonucleosides of 2-thioxopyrido [2,3-d]pyrimidines by phase transfer catalysis and their antimicrobial activity

Article abstract of DOI:10.1080/10426509808033729

The ribonucleosides viz; 2-thioxo-3,5,7-trisubstituted-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl) pyrido[2,3-d]pyrimidine-4 (1H)-ones have been synthesized via phase transfer ribosylation of 2-thioxo- 3,5,7-trisubstituted pyrido[2,3-d)pyrimidine-4(1H)-ones with 2,3,5-tri-O-benzoyl-β-D- ribofuranosyl bromide in biphasic solvent such as CH₂Cl₂-50% aqueous NaOH using tetrabutylammonium bromide as phase transfer catalysis (PTC). The synthesized compounds have been characterized by elemental analyses, spectral data and screened for their antimicrobial activity.

Full text of DOI:10.1080/10426509808033729

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Phosphorus, Sulfur, and Silicon
and the Related Elements
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SYNTHESIS OF
RIBONUCLEOSIDES OF
2-THIOXOPYRIDO [2,3-
d]PYRIMIDINES BY PHASE
TRANSFER CATALYSIS AND
THEIR ANTIMICROBIAL ACTIVITY
Hemlata Agrawal a , Swati a , Ashok K. Yadav a &
Lalit Prakash a
a Department of Chemistry , University of
Rajasthan , Jaipur, 302004, India
Published online: 24 Sep 2006.
To cite this article: Hemlata Agrawal , Swati , Ashok K. Yadav & Lalit Prakash (1998)
SYNTHESIS OF RIBONUCLEOSIDES OF 2-THIOXOPYRIDO [2,3-d]PYRIMIDINES BY PHASE
TRANSFER CATALYSIS AND THEIR ANTIMICROBIAL ACTIVITY, Phosphorus, Sulfur, and
Silicon and the Related Elements, 141:1, 159-166, DOI: 10.1080/10426509808033729
To link to this article: http://dx.doi.org/10.1080/10426509808033729
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