Bioorganic and Medicinal Chemistry Letters p. 949 - 954 (1997)
Update date:2022-08-05
Topics:
Greenspan, Paul D.
Main, Alan J.
Bhagwat, Shripad S.
Barsky, Lester I.
Doti, Robert A.
Engle, Alan R.
Frey, Lisa M.
Zhou, Huanghai
Lipson, Kenneth E.
Chin, Michael H.
Jackson, Robert H.
Uziel-Fusi, Susan
A series of N-aryl cinnamides has been prepared and assayed for antagonism of the leukotriene B4 receptor. Several compounds in this series were found to be highly potent antagonists of the human neutrophil receptor, based on a whole cell binding assay, as well as a neutrophil aggregation assay. This series is unique among LTB4 antagonists, due to its high degree of rigidity.
View MoreLianyungang Ningkang Chemical Co., Ltd
Contact:.+86-518-88588008
Address:http://www.chemnk.com
Contact:+86-21-61318535
Address:Building 29,No.2139 Xizha Road, Fengxian District, Shanghai
ANHUI CHEM-BRIGHT BIOENGINEERING CO.,LTD
Contact:86-561-4080321
Address:No.8 Lieshan Industrial Zone of Huaibei
Contact:+86-574-87065746
Address:10th Floor, No.787 Baizhang East Road,
Contact:+86-532-80762375
Address:No. 6, Hongkong Middle Road, Qingdao, China
Doi:10.1002/adsc.201300447
(2013)Doi:10.1016/0022-328X(68)80047-6
(1968)Doi:10.1021/jo100853b
(2010)Doi:10.1039/J19680000554
()Doi:10.1021/acs.orglett.7b03337
(2017)Doi:10.1021/jm9605849
(1997)