A novel class of conformationally restricted oligonucleotide analogues: Synthesis of 2′,3′-bridged monomers and RNA-selective hybridisation

Article abstract of DOI:10.1039/a608231i

A novel 2′,3′-bicyclic nucleoside 5 has been synthesised and incorporated into oligonucleotide analogues resulting in strong and selective binding to an RNA complement.