Enantiospecific synthesis of γ-keto-α,β-diamino acid derivatives. Stereoselective synthesis of a precursor of streptolidine lactam

Article abstract of DOI:10.1016/S0040-4039(96)02389-1

The reaction of dimethyl (4S,5S)-1-benzyl-2-oxo-3-(9'-phenylfluoren-9'-yl)-imidazolidine 4,5-dicarboxylate (3) with several organolithium reagents afforded the corresponding enantiomerically pure monoketones (4a-e) in good to excellent yields. Chloromethy