Asymmetric synthesis of amino sugars. Part 1: Stereoselective synthesis of (2S,3S,4R,5S)-2-amino-1,3,4,5,6-hexanepentol derivatives and their conversion to L-mannosamine derivatives

Article abstract of DOI:10.1016/S0040-4039(99)00978-8

A novel approach for asymmetric synthesis of amino sugars is developed, starting from readily available chiral building blocks 1 and 2,3-O- isopropylideneglyceraldehyde 2, via the Julia olefination and subsequent dihydroxylation as key steps.