Journal of Organic Chemistry p. 5048 - 5056 (1997)
Update date:2022-08-03
Topics:
Galatsis, Paul
Millan, Scott D.
Ferguson, George
We have modified the substrate used in deconjugative aldol-cyclizations by incorporating the Evans chiral auxiliary. The deconjugative aldol step, using boron enolates, gave the expected products with complete syn-aldol stereochemistry. These compounds could then undergo an iodine-mediated cyclization to form optically active products. Oxetanes and fused ring tetrahydrofurans were easily assembled with a variety of substitutiion patterns and with excellent enantiocontrol. The deconjugation of acyclic chiral enimides resulted in the loss of control of olefin geometry. However, these compounds did appear to cyclize with excellent enantiocontrol.
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Doi:10.1016/S0040-4020(97)00513-9
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(1997)