Bioorganic and Medicinal Chemistry Letters p. 1875 - 1878 (1997)
Update date:2022-08-03
Topics:
Hong, Chang Yong
Kim, Se Ho
Kim, Young Kwan
A novel 5-amino-6-methylquinoline carboxylic acid was synthesized from 2,3,4-trifluoro aniline in 12 steps and coupled with various types of amines to furnish new quinolone antibacterial agents. Depending on the structure of amine, some of quinolones showed comparable activity to ciprofloxacin or better Gram positive activity than ciprofloxacin, demonstrating that the C6 fluorine atom is not a necessary requirement for good antibacterial potency.
View MoreBeijing ZhongDaXinHe Chemical Product Co.,Ltd(expird)
Contact:010-52876516
Address:tongzhoubeiyuan
Contact:86+21-56421993
Address:3F,BUILDING 10,NO.2889 JINKE ROAD, SHANGHAI.
LianYunGang Chiral Chemical(CHINA) CO.,LTD
Contact:+86-518-83616958 +86-519-82884848
Address:LianYunGang Chemical Industry Park (JiangSu)
Contact:+86-574-89075960
Address:#100 Xiang Yun Road, New High tech area, Ningbo, China
KangZhiYuan Pharmaceutical Company Limited
Contact:(Sabrina)86-20-85273232
Address:4th floor, building B, Dadi industry zone, Tangxia, Tianhe, Guangzhou, China
Doi:10.1002/jhet.5570370449
(2000)Doi:10.1016/S0968-0896(97)00051-5
(1997)Doi:10.1016/j.tet.2016.07.031
(2016)Doi:10.1016/0009-3084(67)90009-6
(1966)Doi:10.1007/BF00758665
(1981)Doi:10.1016/S0040-4039(98)01880-2
(1998)
