Replacement of the phosphodiester linkage in oligonucleotides by heterocycles: The effect of triazole- and imidazole-modified backbones on DNA/RNA duplex stability

DOI: 10.1016/S0960-894X(97)00270-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1553 - 1556 (1997)

Update date:2022-09-26

Topics:

Authors:

Von Matt, Peter

Altmann, Karl-Heinz

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)00270-9

Thymidine dinucleotide analogs with imidazole-derived backbones (III and IV) were synthesized. These modified dimeric building blocks were incorporated into oligodeoxyribonucleotides. The hybridization affinity of the modified oligonucleotides for RNA complements was determined and compared to the corresponding olefinic modifications I and II.

Full text of DOI:10.1016/S0960-894X(97)00270-9

Products guided by the article

Product name:1-[(2R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-((E)-styryl)-tetrahydro-furan-2-yl]-3-(4-methoxy-benzyloxymethyl)-5-methyl-1H-pyrimidine-2,4-dione

Cas No:192652-86-1

R&D Labs maybe for 192652-86-1

Shanghai Longjin Metallic Material Co., Ltd.

website:http://www.shlongjin.cn/

Contact:021-56517503,56502257

Address:No.16, Lane 555, Chengyin Road, Shanghai
SHANDONG AONA CHEMICAL CO.,LTD.

Contact:86-532-85762926

Address:LIUYUAN TOWN, ZAOZHUANG CITY, SHANGDONG PROVINCE.
JIANGXI ZHANGFENG CHEMICAL CO., LTD.

Contact:+86-0799-3413066

Address:Xiyuan village, Xiabu Town, Xiangdong District
Zhejiang Hoshine Silicon Industry Co., Ltd.

Contact:86-573-89179966

Address:Zhapu Town, Pinghu City, Zhejiang, China
SJZ Chenghui Chemical Co., Ltd.

Contact:86-311-87713916

Address:no.368 youyi north avenue

Relevant to this article

Studies in marine macrolide synthesis: Stereocontrolled synthesis of the F-ring subunit of spongistatin 1 (Altohyrtin A).

Doi:10.1016/S0040-4039(97)01257-4
(1997)
Stereoselective Grignard reactions to α-amino nitrones. Synthesis of optically active α-aminohydroxylamines and 1,2-diamines

Doi:10.1016/S0957-4166(97)00250-4
(1997)
Synthesis, structure, and reactivity of iridacyclohexadienone and iridaphenol complexes

Doi:10.1021/ja971721+
(1997)
Doi:10.1039/j39680002253
(1968)
Doi:10.1021/ja01148a101
(1951)
Synthesis of diiridium complexes containing bridging thiolate and thioether ligands [(η⁵-C₅Me₅)Ir(μ-SR) (μ-MeSR) -Ir(η⁵-C₅Me₅)] [OSO₂CF₃] (R-Prⁱ, cyclohexyl) and their reactivities toward CO and H₂

Doi:10.1016/s0020-1693(97)05709-5
(1997)

Article Doi