A chiral (alkoxy)methyl-substituted silicon group as an auxiliary for the stereoselective cuprate addition to α,β-unsaturated ketones: Synthesis of (-)-(R)-phenyl 2-phenylpropyl ketone

DOI: 10.1016/S0957-4166(97)00134-1

Source and publish data:

Tetrahedron Asymmetry p. 1587 - 1603 (1997)

Update date:2022-08-03

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Authors:

Bratovanov, Svetoslav

Bienz, Stefan

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Article abstract of DOI:10.1016/S0957-4166(97)00134-1

The [(benzyloxy)methyl](tert-butyl)methylsilyl group was used as the chiral auxiliary to effect highly diastereoselective conjugate additions of organocuprates to enones. Thus, reaction of several R₂CuLi with α-silylated α,β-unsaturated ketones

Full text of DOI:10.1016/S0957-4166(97)00134-1

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Product name:2-Buten-1-one, 2-[(1,1-dimethylethyl)dimethylsilyl]-1-phenyl-, (E)-

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