Catalytic enantioselective addition of hydrogen cyanide to benzaldehyde and p-methoxybenzaldehyde using cyclo-His-(αMe)Phe as catalyst

DOI: 10.1016/S0957-4166(97)00178-X

Source and publish data:

Tetrahedron Asymmetry p. 1987 - 1999 (1997)

Update date:2022-08-03

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Authors:

Hulst, Ron

Broxterman, Quirinus B.

Kamphuis, Johan

Formaggio, Fernando

Crisma, Marco

Toniolo, Claudio

Kellogg, Richard M.

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Article abstract of DOI:10.1016/S0957-4166(97)00178-X

Two cyclo-dipeptides based on His and the unnatural (αMe)Phe have been examined as catalysts in the enantioselective addition of hydrogen cyanide to benzaldehyde and p-methoxy-benzaldehyde. The synthesis, catalytic activity and NMR study towards the mechanism of this reaction are presented.

Full text of DOI:10.1016/S0957-4166(97)00178-X

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