Tetrahedron Letters p. 5253 - 5256 (1997)
Update date:2022-09-26
Topics:
Maligres, Peter E.
See, Marjorie M.
Askin, David
Reider, Paul J.
Nosylaziridines are highly reactive electrophiles towards a variety of nucleophiles yielding the corresponding SN2 adducts without competing attack on the nosyl functionality (SNAr). The resulting primary nosylamide adducts can he readily cleaved under mild conditions to provide the primary amines.
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