New neplanocin analogues. VIII. Synthesis and biological activity of 6'- C-ethyl, -ethenyl, and -ethynyl derivatives of neplanocin A

DOI: 10.1248/cpb.45.1163

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1163 - 1168 (1997)

Update date:2022-07-31

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Authors:

Shuto, Satoshi

Obara, Takumi

Saito, Yasuyoshi

Yamashita, Kanako

Tanaka, Motohiro

Sasaki, Takuma

Andrei, Graciela

Snoeck, Robert

Neyts, Johan

Padalko, Elisabeth

Balzarini, Jan

De Clercq, Erik

Matsuda, Akira

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Article abstract of DOI:10.1248/cpb.45.1163

This report describes the synthesis and antiviral effects of (6'R)-6'- C-ethynyl, -ethenyl, and -ethyl derivatives of neplanocin A (7a, 8a, and 9a, respectively) and the corresponding 6'S-diastereomers (7b, 8b, and 9b, respectively), as examples of 6'-C-s

Full text of DOI:10.1248/cpb.45.1163

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