
Journal of the American Chemical Society p. 4392 - 4398 (1989)
Update date:2022-08-05
Topics:
Imamoto, Tsuneo
Takiyama, Noboyuki
Nakamura, Kimikazu
Hatajima, Toshihiko
Kamiya, Yasuo
The addition of Grignard reagents to ketones is significantly enhanced by cerium chloride with remarkable supression of side reactions, particularly enolization.Some esters, which are prone to side reactions, also react readily with Grignard reagents in the presence of cerium chloride to give normal reaction products in reasonable to high yields.
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