Tetrahedron Asymmetry p. 2299 - 2302 (1997)
Update date:2022-08-05
Topics:
Evans, Colleen A.
Hewgill, Randolph T.
Mansour, Tarek S.
The synthesis of 2'-phosphonomethyl(3',4'-dihydroxylbutyl) nucleotides of cytosine and guanine 13 and 15 possessing the 2'S,3'S absolute configuration was readily accomplished in eleven and ten steps respectively from L-ascorbic acid via the protected tetrols 9 and 8. Alcohol 8 undergoes efficiently a regiospecific Mitsunobu coupling with 6-chloro-2-aminopurine to furnish the N-9 isomer which was further transformed to 15.
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Doi:10.1016/s0020-1693(97)05598-9
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