New efficient syntheses of α-difluoromethyl- and α-trifluoromethyl-ornithine

DOI: 10.1016/S0040-4039(97)01344-0

Source and publish data:

Tetrahedron Letters p. 5965 - 5966 (1997)

Update date:2022-08-03

Topics:

Authors:

Osipov, Sergey N.

Golubev, Alexander S.

Sewald, Norbert

Burger, Klaus

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Article abstract of DOI:10.1016/S0040-4039(97)01344-0

A new efficient method for the preparation of ornithine derivatives 3-5 is described. The key step of the synthesis is the regioselective alkylation of imine 2 with propargyl amine 1.

Full text of DOI:10.1016/S0040-4039(97)01344-0

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Product name:3-Pentynoic acid, 5-amino-2-(difluoromethyl)-2-[[(phenylmethoxy)carbonyl]amino]-, methyl ester

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