Synthesis of th C1-C16 fragment of the marine toxin, laulimalide

Article abstract of DOI:10.1016/S0040-4039(97)01336-1

The synthesis of the C₁-C₁₆ fragment of laulimalide 1, isolated from an Indonesian sponge, is described. The key step in the synthesis of this fragment involves an asymmetric induction by the Evans chiral oxazolidinone protocol.