Chemoenzymatic solution- and solid-phase synthesis of O-glycopeptides of the mucin domain of MAdCAM-1. A general route to O-LacNAc, O-sialyl-LacNAc, and O-Sialyl-Lewis-X peptides

DOI: 10.1021/ja971383c

Source and publish data:

Journal of the American Chemical Society p. 8766 - 8776 (1997)

Update date:2022-07-30

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Authors:

Seitz, Oliver

Wong, Chi-Huey

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Article abstract of DOI:10.1021/ja971383c

An efficient and general method for the solid-phase synthesis of glycopeptides containing an O-linked sialyl-Lewis-X (SLe(x)) tetrasaccharide is described. Using a combined chemoenzymatic approach, the first synthesis of an unnatural β-O-linked SLe(x) att

Full text of DOI:10.1021/ja971383c

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