Bioorganic and Medicinal Chemistry Letters p. 2317 - 2322 (1996)
Update date:2022-08-04
Topics:
Deprez, Pierre
Guillaume, Jacques
Dumas, Jacques
Vevert, Jean-Paul
Synthesis and structure activity relationships of a series of thiol inhibitors of the endothelin-converting enzyme (ECE) are presented. Optimisation of the stereochemistry as well as of the P'1 and P'2 residues led to inhibitors with similar potency to that of phosphoramidon.
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