Thiol inhibitors of endothelin-converting enzyme

DOI: 10.1016/0960-894X(96)00420-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2317 - 2322 (1996)

Update date:2022-08-04

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Authors:

Deprez, Pierre

Guillaume, Jacques

Dumas, Jacques

Vevert, Jean-Paul

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Article abstract of DOI:10.1016/0960-894X(96)00420-9

Synthesis and structure activity relationships of a series of thiol inhibitors of the endothelin-converting enzyme (ECE) are presented. Optimisation of the stereochemistry as well as of the P'₁ and P'₂ residues led to inhibitors with similar potency to that of phosphoramidon.

Full text of DOI:10.1016/0960-894X(96)00420-9

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