Tetrahedron p. 13315 - 13322 (1997)
Update date:2022-07-29
Topics:
Kitano, Kenji
Miura, Shinji
Ohrui, Hiroshi
Meguro, Hiroshi
2-Deoxy-D-erythro-, ribo-, and arabino-pentofuranosylcytosines, which have a fluoromethyl group at the 4'-position, were synthesized. Introduction of fluorine was achieved by DAST treatment of 4-C-hydoxymethy]-D-ribofuranose, the key intermediate of 4'-C-methylnucleosides. Among these nucleosides, the 2'-deoxy derivative exhibited potent antineoplastic activity in vitro.
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