The synthesis of 8,8-disubstituted tricyclic analogs of artemisinin

DOI: 10.1016/S0960-894X(97)00432-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2357 - 2362 (1997)

Update date:2022-07-29

Topics:

Authors:

Haraldson, Chad A.

Karle, Jean M.

Freeman, Sandy G.

Duvadie, Rohit K.

Avery, Mitchell A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)00432-0

Two tricyclic analogs of artemisinin were designed based on a Comparative Molecular Field Analysis (CoMFA) model, and synthesized for antimalarial testing as part of a program to construct and validate modeling tools for drug design of novel antimlarial agents based on the natural product lead, (+)-artemisinin.

Full text of DOI:10.1016/S0960-894X(97)00432-0

Products guided by the article

Product name:3-(4-Methyl-2-oxo-4-phenyl-cyclohexyl)-propionic acid ethyl ester

Cas No:197523-42-5

R&D Labs maybe for 197523-42-5

Feis International Trade Co,. Ltd

Contact:13961823444-18235944442

Address:Wuxi jiangsu
Zhejiang Newfine Industry Co.,Ltd.

Contact:+86-573-82262042

Address:No.225,Dongqing Road, garoms@163.com
MiHecb Bio-Tech Co., Ltd.

Contact:+86-0592 5353131

Address:No.56 Guani Road Software Park 2,Siming District
Dragon Chemical Co., Ltd.

Contact:0571-

Address:zhejing
shandong zhongke taidou chemical co.,ltd

Contact:86-531-88682301

Address:Jinan shandong Province CHina

Relevant to this article

Practical synthetic method of (2Z,3E)-1,4-Diphenylbutadiene T-2639, an inhibitor of plasminogen activator inhibitor-1 (PAI-1) production

Doi:10.1021/op9000719
(2009)
Doi:10.1039/j39680001777
(1968)
Boron trifluoride-acetic anhydride catalysed rearrangement of dihydroarteannuin B

Doi:10.1016/S0040-4020(97)01049-1
(1997)
Synthesis and antitumour activity of new derivatives of flavone-8-acetic acid (FAA). Part 2: Ring-substituted derivatives

Doi:10.1002/ardp.19973300706
(1997)
A Mutasynthesis Approach with a Penicillium chrysogenum ΔroqA Strain Yields New Roquefortine D Analogues

Doi:10.1002/cbic.201402686
(2015)
The synthesis, properties, and reactivities of free-base- and Zn(II)-N-methyl hydroporphyrin compounds. The unexpected selectivity of the direct methylation of free-base hydroporphyrin compounds

Doi:10.1021/ja972210q
(1997)

Article Doi