The synthesis of 8,8-disubstituted tricyclic analogs of artemisinin

DOI: 10.1016/S0960-894X(97)00432-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2357 - 2362 (1997)

Update date:2022-07-29

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Authors:

Haraldson, Chad A.

Karle, Jean M.

Freeman, Sandy G.

Duvadie, Rohit K.

Avery, Mitchell A.

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Article abstract of DOI:10.1016/S0960-894X(97)00432-0

Two tricyclic analogs of artemisinin were designed based on a Comparative Molecular Field Analysis (CoMFA) model, and synthesized for antimalarial testing as part of a program to construct and validate modeling tools for drug design of novel antimlarial agents based on the natural product lead, (+)-artemisinin.

Full text of DOI:10.1016/S0960-894X(97)00432-0

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