Evaluation of piperidinoethoxy moiety as an antiestrogenic substituent in non-steroidal anti-estrogens: Fertility regulation

DOI: 10.1016/S0960-894X(97)00379-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2131 - 2136 (1997)

Update date:2022-07-29

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Authors:

Tripathi, Sachi

Dwivedy, Indra

Dhar Dhar

Dwivedy, Anila

Suprabhat, Ray

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Article abstract of DOI:10.1016/S0960-894X(97)00379-X

A piperidinoethoxy substituent in non-steroidal antiestrogens has a relatively higher antiestrogenic effect as compared to a pyrrolidinoethoxy moiety. However, the antagonistic activity is more depended on the molecular geometry than the nature of the basic chain. No significant difference in the antifertility activity in these two sets of compounds was observed.

Full text of DOI:10.1016/S0960-894X(97)00379-X

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