Syntheses of optically active γ-ketothiols and the esters by lipase-catalyzed hydrolysis via α-acetylthiomethylation of ketones

Article abstract of DOI:10.1016/S0957-4166(97)00281-4

The α-acetylthiomethylation of ketones was achieved by the reaction of ketones or the enamines with N,N-bis-(acetylthiomethyl)-p-chloroaniline in the presence of trifluoroacetic acid. The resulting thiolesters were hydrolyzed enantioselectively by catalys