Ethyl 3-iodo-4,4,4-trifluoro-2(Z)-butenoate: Regio- and stereo-specific preparation and palladium-catalyzed reaction with terminal alkynes

Article abstract of DOI:10.1016/S0040-4039(97)01538-4

Ethyl 3-iodo-4,4,4-trifluoro-2(Z)-butenoate (2) was regio- and stereospecific prepared from ethyl 4,4,4-trinuoro-2-butynote (1). The Sonogashira reaction of 2 with terminal alkynes afforded the (2Z)-en-4-ynoic acid derivatives containing trifluoromethyl g