Chemical and Pharmaceutical Bulletin p. 1676 - 1682 (1998)
Update date:2022-08-03
Topics:
Miyajima, Keisuke
Nekado, Takahiro
Ikeda, Kiyoshi
Achiwa, Kazuo
Conjugates (3-5) of Tn, sialyl Tn and HIV-1-derived peptide antigen with a N-tetradecanoyl L-serine-β-alanine-containing D-glucosamine derivative, structurally related to lipid A, as an immunoadjuvant for the development of totally synthetic vaccines against cancers or HIV were synthesized. The mitogenic activity of compounds 3, 4 and 5 was stronger than that of lipid A analogs (1, 2).
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Doi:10.1007/BF01165915
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