Synthesis of Tn, sialyl Tn and HIV-1-derived peptide antigen conjugates having a lipid a analog as an immunoadjuvant for synthetic vaccines

DOI: 10.1248/cpb.46.1676

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1676 - 1682 (1998)

Update date:2022-08-03

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Authors:

Miyajima, Keisuke

Nekado, Takahiro

Ikeda, Kiyoshi

Achiwa, Kazuo

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Article abstract of DOI:10.1248/cpb.46.1676

Conjugates (3-5) of Tn, sialyl Tn and HIV-1-derived peptide antigen with a N-tetradecanoyl L-serine-β-alanine-containing D-glucosamine derivative, structurally related to lipid A, as an immunoadjuvant for the development of totally synthetic vaccines against cancers or HIV were synthesized. The mitogenic activity of compounds 3, 4 and 5 was stronger than that of lipid A analogs (1, 2).

Full text of DOI:10.1248/cpb.46.1676

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