Journal of Carbohydrate Chemistry p. 555 - 569 (1996)
Update date:2022-08-03
Topics:
Niklasson, Gunilla
Kvarnstroem, Ingemar
Classon, Bjoern
Samuelsson, Bertil
Nillroth, Ulrika
Danielson, Helena
Karlen, Anders
Hallberg, Anders
D-Mannitol was used as precursor for the synthesis of acyclic C2 symmetric potential HIV-1 protease inhibitors. The 1-and 6-hydroxy groups of D-mannitol were substituted by -NHBoc, -NHValZ, -SAr, -SOAr and -SO2Ar and the 2-and 5-hydroxy groups were benzylated. In some products one of the central hydroxyl groups was either inverted or deoxygenated. Despite a close structural similarity to previously published inhibitors none of the products showed significant inhibitory activity against HIV-1 protease.
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