
Angewandte Chemie - International Edition p. 1068 - 1071 (2011)
Update date:2022-08-03
Topics:
Schrittwieser, Joerg H.
Resch, Verena
Sattler, Johann H.
Lienhart, Wolf-Dieter
Durchschein, Katharina
Winkler, Andreas
Gruber, Karl
MacHeroux, Peter
Kroutil, Wolfgang
Bridging the gap: The berberine bridge enzyme (BBE) was employed for the first preparative oxidative biocatalytic C-C coupling that leads to a new intramolecular bond. This unique transformation requires O2 as sole stoichiometric oxidant and gives access to novel optically pure (S)-berbine 2 and (R)-1-benzyl-1,2,3,4-tetrahydroisoquinoline 1 alkaloid derivatives by kinetic resolution.
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