Regioselectivity of the Mannich reaction on pyrrolo[2,3-d]pyrimidine nucleosides related to 7-deaza-2'-deoxyadenosine or 7-deaza-2'-deoxyguanosine

DOI: 10.1055/s-1997-1305

Source and publish data:

Synthesis p. 1067 - 1072 (1997)

Update date:2022-08-03

Topics:

Authors:

Seela, Frank

Chen, Yaoming

Zulauf, Matthias

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Article abstract of DOI:10.1055/s-1997-1305

Mannich reactions were performed on 7-deazapurine 2'-deoxyribonucleosides and the regioselectivity was studied. 7-Deaza-2'-deoxy-adenosine (2'-deoxytubercidin, 4a) furnished the 7-substituted Mannich base 5a. The side chain was introduced in the 8-positio

Full text of DOI:10.1055/s-1997-1305

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