Bioorganic and Medicinal Chemistry Letters p. 2537 - 2542 (1997)
Update date:2022-07-29
Topics:
Fisher, Matthew J.
Gunn, Bruce P.
Harms, Cathy S.
Kline, Allen D.
Mullaney, Jeffrey T.
Scarborough, Robert M.
Skelton, Marshall A.
Um, Suzane L.
Utterback, Barbara G.
Jakubowski, Joseph A.
Disubstituted 3,4-dihydroisoquinolones that contain an ether-linked benzamidine at C6 and a β-substituted aspartate mimic at C2 offer enhanced affinity for GPIIb-IIIa relative to the non-substituted isoquinolone propionate. Alkyl substituents afforded a 10-fold increase in intrinsic activity while aryl substituents yielded a 40-fold improvement.
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