Bioorganic and Medicinal Chemistry Letters p. 2585 - 2588 (1997)
Update date:2022-08-03
Topics:
Armer, Richard E.
Barlow, Jacqueline S.
Dutton, Christopher J.
Greenway, David H.J.
Greenwood, Sean D.W.
Lad, Nita
Tommasini, Ivan
The proposed ring metabolites of the 8-aminoquinoline antimalarial, pentaquine, 1, have been synthesised and their biological activity as anticoccidial agents investigated in vivo. Several analogues in which this metabolic pathway had been blocked were also synthesised and their anticoccidial activity measured.
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