5-Fluoro-2-methyl-N-[5-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-yl carbonyl)-2-pyridinyl]benzamide (CL-385004) and analogs as orally active arginine vasopressin receptor antagonists

DOI: 10.1016/S0960-894X(99)00279-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1737 - 1740 (1999)

Update date:2022-08-04

Topics:

Authors:

Aranapakam, Venkatesan

Albright, J. Donald

Grosu, George T.

Delos Santos, Efren G.

Chan, Peter S.

Coupet, Joseph

Ru, Xun Ru, Xun

Saunders, Trina

Mazandarani

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Article abstract of DOI:10.1016/S0960-894X(99)00279-6

Synthesis and structure-activity relationships (SAR) of orally active arginine vasopressin (AVP) receptor antagonists are discussed. Potent and orally active AVP receptor antagonists are produced when ring A of VPA-985 (1) is replaced with a 3-pyridinyl unit (2b).

Full text of DOI:10.1016/S0960-894X(99)00279-6

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