Discovery of a novel series of selective MMP inhibitors: Identification of the γ-sulfone-thiols

DOI: 10.1016/S0960-894X(99)00116-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 943 - 948 (1999)

Update date:2022-08-04

Topics:

Authors:

Freskos, John N.

Mischke, Brent V.

DeCrescenzo, Gary A.

Heintz, Robert

Getman, Daniel P.

Howard, Susan C.

Kishore, Nandini N.

McDonald, Joseph J.

Munie, Grace E.

Rangwala, Shaukat

Swearingen, Craig A.

Voliva, Charles

Welsch, Dean J.

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Article abstract of DOI:10.1016/S0960-894X(99)00116-X

We have discovered a new series of potent MMP inhibitors that are selective for MMP-13 over MMP-1 incorporating a γ-sulfone thiol.

Full text of DOI:10.1016/S0960-894X(99)00116-X

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