Bioorganic and Medicinal Chemistry p. 1 - 8 (1998)
Update date:2022-08-04
Topics:
Showell, Graham A.
Emms, Frances
Marwood, Rosemarie
O'Connor, Desmond
Patel, Smita
Leeson, Paul D.
The synthesis of a series of 2,4-disubstituted morpholines is described and their affinities at human dopamine receptors reported. The orally bioavailable 7-azaindole compound 11 has nanomolar affinity at the hD4 receptor with > 1000-fold selectivity over the hD2 receptor.
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Doi:10.1016/0022-328X(83)80031-X
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(1998)
