Analytical Chemistry p. 2218 - 2221 (1986)
Update date:2022-07-30
Topics:
Jacob, Peyton
Benowitz, Neal L.
Yu, Lisa
Shulgin, Alexander T.
Nicotine N-oxide is extracted from urine by use of silica gel columns and eluted with methanolic ammonia.The eluate is evaporated and then heated at 150-160 deg C in anisole, which results in conversion to the ring-expansion product 2-methyl-6-(3-pyridyl)tetrahydro-1,2-oxazine.The oxazine derivative is readily extracted from aqueous solution with organic solvents and has good chromatographic properties.A method for determination of nicotine N-oxide in smoker's urine, using 5-methylnicotine N-oxide as an internal standard, is described.
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