Analytical Chemistry p. 2218 - 2221 (1986)
Update date:2022-07-30
Topics:
Jacob, Peyton
Benowitz, Neal L.
Yu, Lisa
Shulgin, Alexander T.
Nicotine N-oxide is extracted from urine by use of silica gel columns and eluted with methanolic ammonia.The eluate is evaporated and then heated at 150-160 deg C in anisole, which results in conversion to the ring-expansion product 2-methyl-6-(3-pyridyl)tetrahydro-1,2-oxazine.The oxazine derivative is readily extracted from aqueous solution with organic solvents and has good chromatographic properties.A method for determination of nicotine N-oxide in smoker's urine, using 5-methylnicotine N-oxide as an internal standard, is described.
View MoreFUJIAN SHANSHUI CHEMICAL CORP.LTD.
Contact:+86-151-59920036
Address:Jinqiao Gareden, jo@fj-xinyi.com
Contact:+86-571-86491666
Address:SHI XIANG ROAD
Changzhou Hopschain Chemical Co.,Ltd
website:http://www.hopschem.cn/products.html
Contact:86-519-85528066
Address:Room 710, Unit A, Xingbei Development Mansion, Tongjiang Road, Changzhou City,213000, China
Hangzhou Bayee Chemical Co.,Ltd.
Contact:+86-571-86990109
Address:No.380, Jiangnan Auenue, Binjiang District, Hangzhou, China
Contact:1-858-6993322
Address:9883 Pacific Heights Blvd., Suite H, San Diego
Doi:10.3987/COM-10-S(E)66
(2010)Doi:10.1002/(SICI)1521-3773(19990601)38:11<1617::AID-ANIE1617>3.0.CO;2-Z
(1999)Doi:10.1021/ja01316a077
(1934)Doi:10.1021/ja010957h
(2001)Doi:10.1016/S0968-0896(97)10039-6
(1998)Doi:10.1021/js9900957
(1999)
