(3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents

Article abstract of DOI:10.1016/S0960-894X(99)00039-6

A series of 3-[(2,4-dioxothiazolidin-5-yl)methyl]benzamide derivatives was prepared as part of a search for antidiabetic agents. A structure- activity relationship study of these compounds led to the identification of 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[4- (trifluoromethyl)phenyl]methyl]benzamide (KRP-297) as a candidate drug for the treatment of diabetes mellitus.