Diastereoselective Oxidative Coupling of Enolates of Chiral Carboxylic Acid Derivatives

Article abstract of DOI:10.1016/0040-4039(95)00786-C

Enolates of chiral propionic acid amides were oxidatively dimerized with cupric salts or iodine with high simple as well as induced diastereselectivity of up to 99:1.Intramolecular coupling of chiral dienolates of 1,7-heptanediamides led to a 1,2-substituted cyclopentane and a derivative of 1,2,6,7-cyclodecane tetracarboxylic acid.