Synthesis of monoterpenic analogues of puupehenone and puupehedione

DOI: 10.1016/S0040-4039(98)00216-0

Source and publish data:

Tetrahedron Letters p. 2425 - 2428 (1998)

Update date:2022-08-05

Topics:

Authors:

Barrero, Alejandro F.

Alvarez-Manzaneda, Enrique J.

Herrador, M. Mar

Valdivia, Monica V.

Chahboun, Rachid

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Article abstract of DOI:10.1016/S0040-4039(98)00216-0

Compounds 7-8, monoterpenic analogues of the marine metabolites puupehenone (1) and puupehedione (2), were prepared from the easily available β-cylocitral (10) an the aryllithium derived from 11 and 12. 8 showed antitumoral activity 4-10 times higher than that for the natural products.

Full text of DOI:10.1016/S0040-4039(98)00216-0

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