Toward the second-generation synthesis of zaragozic acids: Construction of the 2,8-dioxabicyclo[3.2.1]octane core system via tandem carbonyl ylide formation and 1,3-dipolar cycloaddition sequence

Article abstract of DOI:10.1016/S0040-4039(98)00203-2

A highly efficient construction of the 2,8-dioxabicyclo[3.2.1]octane core structure of zaragozic acids, inhibitors of the enzyme squalene synthase, has been achieved by exploiting the sequence of rhodium(II)- mediated intramolecular carbonyl ylide formati