Total synthesis of the antimycoplasma antibiotic micacocidin

Article abstract of DOI:10.1016/S0040-4039(98)00518-8

A total synthesis of the antimycoplasma antibiotic micacocidin (1) is described. Construction of sterically hindered thiazoline 12 was achieved by a phosphorus pentachloride-mediated cyclization reaction of S-protected aryloylcysteine 11, and compound 1 with desired chirality at C-10 was favorably obtain from diastereomeric mixture 30 through formation of the Zn complex 31.