Toward a total synthesis of pristinamycin II(B); a chiron approach to a C-9/C-16 fragment

Article abstract of DOI:10.1016/S0040-4039(98)00500-0

Copper(I)-catalysed addition of methyl Grignard reagent to the propagyl diol 8, which was efficiently prepared from S-malic acid proceeds with a perfect E stereoselectivity, the diol titus obtained being then converted into the title fragment by known met