Formal synthesis of Manzamine C via a sila-Cope elimination

Article abstract of DOI:10.1016/S0040-4020(98)00270-1

Piperidine derivative 7, prepared in six steps from 2-methylpyridine, afforded by a sila-Cope elimination aminoalcohol 10 which is a direct synthetic precursor of the azaundecene ring of Manzamine C 2.